From Thienodiazepinediones to Thienopyridinones: Flexible Synthesis of Substituted Thieno[3,2-e][1,4]diazepinones and 6-Aminothieno[3,2-b]pyridinones

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• 作者：Yann Brouillette ; Jean Martinez ; Vincent Lisowski
• 刊名：Journal of Organic Chemistry
• 出版年：2009
• 出版时间：July 17, 2009
• 年：2009
• 卷：74
• 期：14
• 页码：4975-4981
• 全文大小：209K
• 年卷期：v.74,no.14(July 17, 2009)
• ISSN：1520-6904

文摘

N-Substituted thienodiazepinedione opening with a series of organomagnesium bromides allowed the subsequent cyclization to the seven-membered ring thieno[3,2-e][1,4]diazepinone in 52−99% yields or to the six-membered ring thieno[3,2-b]pyridinones in 45−55% yields. Effective syntheses introducing considerable diversity onto these valuable scaffolds are described.