Intracellular Adaptation of Brucella abortus

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• 作者：Julie Lamontagne^† ; ; Anik Forest^† ; ; Elena Marazzo^† ; ; Franois Denis^† ; ; Heather Butler^† ; ; Jean-Franois Michaud^† ; <
• 刊名：Journal of Proteome Research
• 出版年：2009
• 出版时间：March 6, 2009
• 年：2009
• 卷：8
• 期：3
• 页码：1594-1609
• 全文大小：729K
• 年卷期：v.8,no.3(March 6, 2009)
• ISSN：1535-3907

文摘

Macrophages were infected with virulent Brucella abortus strain 2308 or attenuated strain 19. Intracellular bacteria were recovered at different times after infection and their proteomes compared. The virulent strain initially reduced most biosynthesis and altered its respiration; adaptations reversed later in infection. The attenuated strain was unable to match the magnitude of the virulent strain’s adjustments. The results provide insight into mechanisms utilized by Brucella to establish intracellular infections.