Determination of a Large Set of 尾-Adrenergic Agonists in Animal Matrices Based on Ion Mobility and Mass Separations

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• 作者：Laure Beucher ; Gaud Dervilly-Pinel ; St茅phanie Pr茅vost ; Fabrice Monteau ; Bruno Le Bizec
• 刊名：Analytical Chemistry
• 出版年：2015
• 出版时间：September 15, 2015
• 年：2015
• 卷：87
• 期：18
• 页码：9234-9242
• 全文大小：372K
• ISSN：1520-6882

文摘

While the coupling of traveling wave ion mobility spectrometry (TWIMS) and mass spectrometry is mainly reported for structural purposes, we studied its potential in enhancing compounds analysis such as growth promoters used in livestock animals at trace concentrations. 尾-Adrenergic agonists have been selected as model compounds since they exhibit a range of close physicochemical properties leading to analytical issues using classical approaches. In this paper, the potential of Synapt G2-S (Q-TWIM-TOF MS) has been investigated for sensitive and specific detection of a range of these synthetic phenethanolamines in various complex biological matrices (retina, meat, and urine) from bovine considered as relevant in the context of detecting 尾-adrenergic agonists use in animals. In particular, the specificity of the additional information provided by the TWIMS (i.e., collision cross section) together with the interest of the extra dimension of separation is discussed.