Tissue Distribution and Transfer to Eggs of Ingested α-Hexabromocyclododecane (α-HBCDD) in Laying Hens (Gallus domesticus)
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- 作者：Elena Dominguez-Romero ; Ronan Cariou ; Elsa Omer ; Philippe Marchand ; Gaud Dervilly-Pinel ; Bruno Le Bizec ; Angélique Travel ; Catherine Jondreville
- 刊名：Journal of Agricultural and Food Chemistry
- 出版年：2016
- 出版时间：March 16, 2016
- 年：2016
- 卷：64
- 期：10
- 页码：2112-2119
- 全文大小：312K
- ISSN：1520-5118
文摘
The aim of the current study was to describe the fate of ingested α-hexabromocyclododecane (α-HBCDD) in laying hens. Individuals were exposed to two dietary concentrations of α-HBCDD (50 and 5 ng g–1 feed) for 18 or 11 weeks followed by a 7-week decontamination period. The results show that no isomerization of α- to β- or γ-HBCDD forms occurred, whereas OH-HBCDD was identified as a product of α-HBCDD metabolism. Irrespective of the level of feed contamination, estimates of steady-state accumulation ratios were 5.2, 3.6, and 9.2 and half-lives were estimated at 17.4, 22.8, and 35.3 days in egg yolk, liver tissue, and abdominal fat, respectively. The steady-state carry-over rate to eggs was 22.9%. Thus, α-HBCDD ingested by laying hens is readily transferred to eggs and significantly accumulates in adipose tissue.