Enantiomeric Segregation in the Gel Phase of Lipid Bilayers

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• 作者：Bruno A. C. Horta ; Philippe H. H眉nenberger
• 刊名：Journal of the American Chemical Society
• 出版年：2011
• 出版时间：June 8, 2011
• 年：2011
• 卷：133
• 期：22
• 页码：8464-8466
• 全文大小：765K
• 年卷期：v.133,no.22(June 8, 2011)
• ISSN：1520-5126

文摘

Enantiospecific interactions within a monoglyceride lipid bilayer are investigated using molecular dynamics simulations. Preferential homochiral interactions are observed in the gel phase, whereas no detectable enantiospecificity is seen in the liquid-crystal phase. On the basis of these results and available experimental data, a mechanism is proposed for the formation of the coagel phase of monoglycerides. Enantiomeric segregation in the gel phase is also discussed in terms of its possible implications for prebiological evolution and membrane raft function.