Carbometalation鈥揅arboxylation of 2,3-Allenols with Carbon Dioxide: A Dramatic Effect of Halide Anion
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- 作者：Suhua Li ; Bukeyan Miao ; Weiming Yuan ; Shengming Ma
- 刊名：Organic Letters
- 出版年：2013
- 出版时间：March 1, 2013
- 年：2013
- 卷：15
- 期：5
- 页码：977-979
- 全文大小：222K
- 年卷期：v.15,no.5(March 1, 2013)
- ISSN：1523-7052
文摘
The cyclic organometallic intermediates formed via CuCl-mediated highly regio- and stereoselective carbomagnesiation of 2,3-allenols with Grignard reagents may smoothly react with carbon dioxide to afford 2(5H)-furanones. A dramatic effect of the halide anion from the Grignard reagent (Br vs Cl) for CO2 activation was observed. The reaction proceeded smoothly under mild conditions to afford the products in 58鈥?3% yields.