A De Novo Approach to the Synthesis of Glycosylated Methymycin Analogues with Structural and Stereochemical Diversity

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• 作者：Svetlana A. Borisova ; Sanjeeva R. Guppi ; Hak Joong Kim ; Bulan Wu ; John H. Penn ; Hung-wen Liu ; George A. O’ ; Doherty
• 刊名：Organic Letters
• 出版年：2010
• 出版时间：November 19, 2010
• 年：2010
• 卷：12
• 期：22
• 页码：5150-5153
• 全文大小：295K
• 年卷期：v.12,no.22(November 19, 2010)
• ISSN：1523-7052

文摘

A divergent and highly stereoselective route to 11 glycosylated methymycin analogues has been developed. The key to the success of this method was the iterative use of the Pd-catalyzed glycosylation reaction and postglycosylation transformation. This unique application of Pd-catalyzed glycosylation demonstrates the breath of α/β- and d/l-glycosylation of macrolides that can be efficiently prepared using a de novo asymmetric approach to the carbohydrate portion.