Bis-spirolabdane Diterpenoids from Leonotis nepetaefolia

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• 作者：Jun Li ; Frank R. Fronczek ; Daneel Ferreira ; Charles L. Burandt ; Jr. ; Vincent Setola ; Bryan L. Roth ; Jordan K. Zjawiony
• 刊名：Journal of Natural Products
• 出版年：2012
• 出版时间：April 27, 2012
• 年：2012
• 卷：75
• 期：4
• 页码：728-734
• 全文大小：391K
• 年卷期：v.75,no.4(April 27, 2012)
• ISSN：1520-6025

文摘

Ten new bis-spirolabdane diterpenoids, leonepetaefolins A鈥揈 (1, 3, 5, 7, 9) and 15-epi-leonepetaefolins A鈥揈 (2, 4, 6, 8, 10), together with eight known labdane diterpenoids (11鈥?b>18) as well as two known flavonoids, apigenin and cirsiliol, were isolated from the leaves of Leonotis nepetaefolia. The structures of the new compounds were determined on the basis of 1D- and 2D-NMR experiments including ¹H, ¹³C, DEPT, ¹H鈥?sup>1H COSY, HSQC, HMBC, and NOESY. The absolute configuration of an epimeric mixture of 1 and 2 was determined by X-ray crystallographic analysis. The compounds isolated were evaluated for their binding propensity in several CNS G-protein-coupled receptor assays in vitro.