Application of GC-MS/MS for the Analysis of Tobacco Alkaloids in Cigarette Filler and Various Tobacco Species

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• 作者：Joseph G. Lisko ; Stephen B. Stanfill ; Bryce W. Duncan ; Clifford H. Watson
• 刊名：Analytical Chemistry
• 出版年：2013
• 出版时间：March 19, 2013
• 年：2013
• 卷：85
• 期：6
• 页码：3380-3384
• 全文大小：213K
• 年卷期：v.85,no.6(March 19, 2013)
• ISSN：1520-6882

文摘

This publication reports the first known use of gas chromatography-tandem mass spectrometry for the quantitation of five minor tobacco alkaloids (nornicotine, myosmine, anabasine, anatabine, and isonicoteine) in various tobacco samples. A summary of the concentrations of these minor alkaloid levels in the filler from 50 popular cigarette brands were found to be 659鈥?86 渭g/g nornicotine, 8.64鈥?7.3 渭g/g myosmine, 127鈥?85 渭g/g anabasine, 927鈥?390 渭g/g anatabine, and 23.4鈥?5.5 渭g/g isonicoteine. Levels of minor alkaloids found in reference cigarettes (1R5F, 2R4F, 3R4F, CM4, and CM6) as well as burley, flue-cured, oriental, reconstituted, and Nicotiana rustica and Nicotiana glauca tobacco types are also reported. Quantitation of the minor tobacco alkaloids is important because the alkaloids have been shown to be precursors of carcinogenic tobacco specific N鈥?nitrosamines.