Manganese-Catalyzed Carboacylations of Alkenes with Alkyl Iodides

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• 作者：Caitlin M. McMahon ; Matthew S. Renn ; Erik J. Alexanian
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：August 19, 2016
• 年：2016
• 卷：18
• 期：16
• 页码：4148-4150
• 全文大小：301K
• 年卷期：0
• ISSN：1523-7052

文摘

A manganese-catalyzed carboacylation of alkenes with alkyl iodides and carbon monoxide is described. This carbonylative difunctionalization uses both primary and secondary alkyl iodides in reactions with a diverse array of cyclic and acyclic substrates. Examples of successful applications to the synthesis of five-, six-, and seven-membered rings are provided. The inexpensive, first-row catalytic system and mild reaction conditions are expected to facilitate applications in complex synthesis.