Bioactive Sesquiterpenoids from the Rhizomes of Acorus calamus
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- 作者：Zhi-You Hao ; Dong Liang ; Huan Luo ; Yan-Fei Liu ; Gang Ni ; Qing-Jian Zhang ; Li Li ; Yi-Kang Si ; Hua Sun ; Ruo-Yun Chen ; De-Quan Yu
- 刊名：Journal of Natural Products
- 出版年：2012
- 出版时间：June 22, 2012
- 年：2012
- 卷：75
- 期：6
- 页码：1083-1089
- 全文大小：286K
- 年卷期：v.75,no.6(June 22, 2012)
- ISSN：1520-6025
文摘
Eight new sesquiterpenes (1鈥?b>8) and one new norsesquiterpene (9) named calamusins A鈥揑 were isolated from the ethanol extract of Acorus calamus rhizomes. The absolute configuration of compound 8 was determined by comparing its experimental and calculated ECD spectra. The absolute configurations of the other compounds were determined from their CD spectra. Furthermore, in in vitro assays, compounds 3, 4, 7, and 9 (10 渭M) exhibited weak hepatoprotective activities against APAP-induced HepG2 cell damage.