pH-Responsive Aggregates from Double Hydrophilic Block Copolymers Carrying Zwitterionic Groups. Encapsulation of Antiparasitic Compounds for the Treatment of Leishmaniasis
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- 作者：Nikos Karanikolopoulos ; Marinos Pitsikalis ; Nikos Hadjichristidis ; Kalliopi Georgikopoulou ; Theodora Calogeropoulou ; John R. Dunlap
- 刊名：Langmuir
- 出版年：2007
- 出版时间：April 10, 2007
- 年：2007
- 卷：23
- 期：8
- 页码：4214 - 4224
- 全文大小：571K
- 年卷期：v.23,no.8(April 10, 2007)
- ISSN：1520-5827
文摘
A series of well-defined poly[(ethylene oxide)-b-2-(dimethylamino)ethyl methacrylate] (PEO-b-PDMAEMA) diblockcopolymers were synthesized by atom transfer radical polymerization (ATRP) techniques. Post-polymerization reactionswere performed to transform a portion of the tertiary amine groups of the PDMA
MA into phosphorozwitterions.The aggregation behavior of the prepared zwitterionic block copolymers was investigated by static and dynamic lightscattering techniques at 25 and 37 
C, in weakly basic and acidic aqueous solutions. Antiparasitic drugs used for thetreatment of Leishmania were incorporated into the copolymer aggregates. The effect of the solution pH, the zwitterioncontent, temperature, and the quantity of the incorporated drug on the aggregation behavior of the copolymers wastested.
MA into phosphorozwitterions.The aggregation behavior of the prepared zwitterionic block copolymers was investigated by static and dynamic lightscattering techniques at 25 and 37 C, in weakly basic and acidic aqueous solutions. Antiparasitic drugs used for thetreatment of Leishmania were incorporated into the copolymer aggregates. The effect of the solution pH, the zwitterioncontent, temperature, and the quantity of the incorporated drug on the aggregation behavior of the copolymers wastested.