Preparation of an Antibacterial Poly(ionic liquid) Graft Copolymer of Hydroxyethyl Cellulose

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• 作者：Fanny Joubert ; R. Paul Yeo ; Gary J. Sharples ; Osama M. Musa ; David R. W. Hodgson ; Neil R. Cameron
• 刊名：Biomacromolecules
• 出版年：2015
• 出版时间：December 14, 2015
• 年：2015
• 卷：16
• 期：12
• 页码：3970-3979
• 全文大小：589K
• ISSN：1526-4602

文摘

Poly(ionic liquid)s (P(IL)s) of different degrees of polymerization (10, 50, and 100) were prepared via RAFT polymerization using an alkyne-terminated xanthate as transfer agent, with a monomer conversion of up to 鈭?0% and a 膼_M of 1.5 for P(IL)₁₀₀. Subsequently, P(IL) chains were coupled to ¹⁵N-labeled azido-functionalized hydroxyethyl cellulose (HEC), forming graft copolymers of HEC with different chain length and graft densities, which were characterized using (¹³C and ¹⁵N) CP-MAS NMR and FT-IR spectroscopies. The antibacterial activities of HEC-g-P(IL)s were tested against Escherichia coli and Staphylococcus aureus and were comparable to ampicillin, a well-known antibiotic, demonstrating efficient activity of the graft copolymers against bacteria. Moreover, HEC-g-P(IL)s were slightly more effective against E. coli than S. aureus. A decrease in graft density of P(IL)₁₀ on the HEC backbone decreased the activity of the graft copolymers against both bacteria. These findings suggest that HEC-g-P(IL) could find applications as an antiseptic compound, for example, in paint formulation.