Luminescent Ir(III) Complex Exclusively Made of Polypyridine Ligands Capable of Intercalating into Calf-Thymus DNA
详细信息 查看全文
- 作者：Sebastiano Campagna ; Marco Cavazzini ; Matteo Cusumano ; Maria Letizia Di Pietro ; Antonino Giannetto ; Fausto Puntoriero ; Silvio Quici
- 刊名：Inorganic Chemistry
- 出版年：2011
- 出版时间：November 7, 2011
- 年：2011
- 卷：50
- 期：21
- 页码：10667-10672
- 全文大小：845K
- 年卷期：v.50,no.21(November 7, 2011)
- ISSN：1520-510X
文摘
Efficient intercalation of a luminescent Ir(III) complex exclusively made of polypyridine ligands in natural and synthetic biopolymers is reported for the first time. The emission of the complex is largely enhanced in the presence of [poly(dA鈥揹T)2] and strongly quenched in the presence of [poly(dG鈥揹C)2]. By comparing the emission decays in DNA and in synthetic polynucleotides, it is proposed that the emission quenching of the title compound by guanine residues in DNA is no longer effective over a distance of four dA鈥揹T base pairs.