Drug Synthesis and Analysis on a Dime: A Capstone Medicinal Chemistry Experience for the Undergraduate Biochemistry Laboratory
详细信息 查看全文
- 作者：Craig N. Streu ; Randall D. Reif ; Kelly Y. Neiles ; Amanda J. Schech ; Pamela S. Mertz
- 刊名：Journal of Chemical Education
- 出版年：2016
- 出版时间：December 13, 2016
- 年：2016
- 卷：93
- 期：12
- 页码：2084-2088
- 全文大小：231K
- ISSN：1938-1328
文摘
Integrative, research-based experiences have shown tremendous potential as effective pedagogical approaches. Pharmaceutical development is an exciting field that draws heavily on organic chemistry and biochemistry techniques. A capstone drug synthesis/analysis laboratory is described where biochemistry students synthesize azo-stilbenoid compounds and test the biological activity of those compounds as well as a known inhibitor on mushroom tyrosinase using UV/vis-based kinetic assays. In this paper, three such successful azo-stilbenoid inhibitors of tyrosinase, representative student generated data, technical aspects of the experiments, and an interpretation of student feedback on the project as a whole are presented.