Influence of Gold Nanoshell on Hyperthermia of Superparamagnetic Iron Oxide Nanoparticles

详细信息    查看全文

• 作者：Faruq Mohammad ; Gopalan Balaji ; Andrew Weber ; Rao M. Uppu ; Challa S. S. R. Kumar
• 刊名：Journal of Physical Chemistry C
• 出版年：2010
• 出版时间：November 18, 2010
• 年：2010
• 卷：114
• 期：45
• 页码：19194-19201
• 全文大小：366K
• 年卷期：v.114,no.45(November 18, 2010)
• ISSN：1932-7455

文摘

A gold nanoshell around superparamagnetic iron oxide nanoparticles (SPIONs) was synthesized, and small-angle X-ray scattering (SAXS) analysis suggests a gold coating of approximately 0.4−0.5 nm thickness. On application of low frequency oscillating magnetic fields (44−430 Hz), a 4−5-fold increase in the amount of heat released with gold-coated SPIONs (6.3 nm size) in comparison with SPIONs (5.4 nm size) was observed. Details of the influence of frequencies of oscillating magnetic field, concentration, and solvent on heat generation are presented. We also show that in the absence of oscillating magnetic field, both SPIONs and SPIONs@Au are not particularly cytotoxic to mammalian cells (MCF-7 breast carcinoma cells and H9c2 cardiomyoblasts) in culture, as indicated by the reduction of 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium by viable cells in a phenazine methosulfate-assisted reaction.