Biomineralization Induced by Stressed Nanobacteria

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• 作者：Andrei P. Sommer ; Anne-Marié ; Pretorius ; E. Olavi Kajander ; and Uri Oron
• 刊名：Crystal Growth & Design
• 出版年：2004
• 出版时间：January 2004
• 年：2004
• 卷：4
• 期：1
• 页码：45 - 46
• 全文大小：25K
• 年卷期：v.4,no.1(January 2004)
• ISSN：1528-7505

文摘

Animal experiments provided direct evidence that myocyte apoptosis may be a causal mechanism of heartfailure, suggesting that inhibition of this cell death process may constitute the basis for novel therapies. The data suggestedthat even inhibition of a small fraction of cardiac myocyte apoptosis could be instrumental in preventing cardiomyopathy.Here we analyze the mechanisms by which nanobacteria (NB) are expected to contribute to the inhibition of cellular functionsin the heart. NB are protected by a nanocrystalline apatite shell. Under environmental stress, they produce a slime providingideal conditions for individual mineralization and rapid formation of giant thrombogenic assemblies. We establish a modelbased upon a possible synergistic impact of physical and chemical stimuli on NB, exposing the principles of a novel preventivestrategy promising to inhibit formation of NB clusters in the circulation.