Preparation of Novel Silicone Multicompartment Particles by Multiple Emulsion Templating and Their Use As Encapsulating Systems

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• 作者：Neus Vilanova ; Conxita Solans ; Carlos Rodr铆guez-Abreu
• 刊名：Langmuir
• 出版年：2013
• 出版时间：December 10, 2013
• 年：2013
• 卷：29
• 期：49
• 页码：15414-15422
• 全文大小：474K
• 年卷期：v.29,no.49(December 10, 2013)
• ISSN：1520-5827

文摘

Multicompartment poly(dimethylsiloxane) particles were produced for the first time using water-in-oil-in-water (W₁/O/W₂) emulsions as templates. Multiple silicone W₁/O/W₂ emulsions were successfully prepared by using silicone precursors with a low viscosity. Several formulation parameters were studied to determine their effect on the properties of emulsions and derived particles. It was observed that the mass fraction of the inner aqueous phase (蠁_W1) and the concentration of both the hydrophobic and hydrophilic surfactants played a crucial role in the morphology and stability of the emulsions. Thus, the derived silicone porous particles also showed different characteristics depending on the emulsion formulation because of the templating effect. At low 蠁_W1 or high concentrations of the hydrophobic surfactant, particles showed smaller pore sizes as a result of more stable inner droplets. On the other hand, high concentrations of the hydrophobic surfactant resulted in an increase in the size of the derived particles, whereas high concentrations of the hydrophilic surfactant caused the opposite effect. In addition, fluorescein was encapsulated into the hydrophobic particles during the synthesis process and released in a controlled manner. The possibility to encapsulate simultaneously but independently two different hydrophilic components inside the same globule was also tested. On the basis of these results, the obtained silicone porous particles are envisioned to have applications in several advanced fields, for instance, as hydrophobic delivery systems.