Gold-Catalyzed Povarov-Type Reaction of Fluorinated Imino Esters and Furans
详细信息 查看全文
- 作者：Álvaro Sanz-Vidal ; Javier Miró ; María Sánchez-Roselló ; Carlos del Pozo ; Santos Fustero
- 刊名：Journal of Organic Chemistry
- 出版年：2016
- 出版时间：August 5, 2016
- 年：2016
- 卷：81
- 期：15
- 页码：6515-6524
- 全文大小：480K
- 年卷期：0
- ISSN：1520-6904
文摘
A gold-catalyzed Povarov-type reaction of fluorinated imino esters and furans is described. The process, which takes place in dichoromethane at room temperature, gives rise to novel fluorinated tetrahydrofuran-fused tetrahydroquinolines in good yields and moderate levels of diastereoselectivity in a very simple manner. The reported examples expand the versatility of the Povarov reaction to unprecedented fluorinated substrates, generating scaffolds that contain quaternary α-amino acid units.