Chemoenzymatic Synthesis of Carbasugars (+)-Pericosines A−C from Diverse Aromatic cis-Dihydrodiol Precursors

详细信息    查看全文

• 作者：Derek R. Boyd ; Narain D. Sharma ; Carmen A. Acaru ; John F. Malone ; Colin R. O’ ; Dowd ; Christopher C. R. Allen ; Paul J. Stevenson
• 刊名：Organic Letters
• 出版年：2010
• 出版时间：May 21, 2010
• 年：2010
• 卷：12
• 期：10
• 页码：2206-2209
• 全文大小：201K
• 年卷期：v.12,no.10(May 21, 2010)
• ISSN：1523-7052

文摘

cis-Dihydrocatechols, derived from biological cis-dihydroxylation of methyl benzoate, iodobenzene and benzonitrile, using the microorganism Pseudomonas putida UV4, were converted into pericosines A, C, and B, respectively. This approach constitutes the shortest syntheses, to date, of these important natural products with densely packed functionalities.