Enantioselective Synthesis of Tertiary Alcohols through a Zirconium-Catalyzed Friedel鈥揅rafts Alkylation of Pyrroles with 伪-Ketoesters
详细信息 查看全文
- 作者：Gonzalo Blay ; Isabel Ferna虂ndez ; M. Carmen Mun虄oz ; Jose虂 R. Pedro ; Alejandro Recuenco ; Carlos Vila
- 刊名：Journal of Organic Chemistry
- 出版年：2011
- 出版时间：August 5, 2011
- 年：2011
- 卷：76
- 期：15
- 页码：6286-6294
- 全文大小：891K
- 年卷期：v.76,no.15(August 5, 2011)
- ISSN：1520-6904
文摘
Chiral complexes of 1,1鈥?bi-2-naphthol-based ligands with zirconium tert-butoxide catalyze the Friedel鈥揅rafts alkylation of pyrroles with 伪-ketoesters to afford tertiary alcohols in good yields and ee up to 98%. The reaction is also of application to 4,7-dihydroindole to give C2-alkylated indoles after oxidation with p-benzoquinone.