Osmium-Mediated Direct C–H Bond Activation at the 8-Position of Quinolines

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• 作者：Miguel A. Esteruelas ; Carmen Larramona ; Enrique Oñate
• 刊名：Organometallics
• 出版年：2016
• 出版时间：June 13, 2016
• 年：2016
• 卷：35
• 期：11
• 页码：1597-1600
• 全文大小：275K
• 年卷期：0
• ISSN：1520-6041

文摘

Metal-mediated direct C–H bond activation at the 8-position of quinolines, which is the essential step for the functionalization of this bond, is promoted by the hexahydride OsH₆(PⁱPr₃)₂. This complex activates quinoline and 2-, 3-, 6-, and 7-methylquinoline to afford the classical trihydride derivatives OsH₃{κ²-C⁸,N-(quinolinyl)}(PⁱPr₃)₂ and OsH₃{κ²-C⁸,N-(quinolinyl-n-Me)}(PⁱPr₃)₂ (n = 2, 3, 6, 7), containing a four-membered heterometalla ring.