A New Family of Doubly Cyclopalladated Diimines. A Remarkable Effect of the Linker between the Metalated Units on Their Cytotoxicity

详细信息    查看全文

• 作者：Joan Albert ; Ramon Bosque ; Magali Cadena ; Luc铆a D鈥橝ndrea ; Jaume Granell ; Asensio Gonz谩lez ; Josefina Quirante ; Carmen Calvis ; Ramon Messeguer ; Josefa Bad铆a ; Laura Baldom脿 ; Teresa Calvet ; Merc猫 Font-Bardia
• 刊名：Organometallics
• 出版年：2014
• 出版时间：June 9, 2014
• 年：2014
• 卷：33
• 期：11
• 页码：2862-2873
• 全文大小：493K
• 年卷期：v.33,no.11(June 9, 2014)
• ISSN：1520-6041

文摘

The cyclopalladation of a series of symmetric diimines with the formula (RC₆H₄CH鈺怤Z)₂, where Z = CH₂ or (CH₂)₂OCH₂ and R = p-Cl, p-OMe, p-NO₂, and o-Cl, is described. Optimal conditions to obtain the dimetalated compounds were found to be palladium(II) acetate, in toluene, at 60 掳C and with a reaction time of 2鈥? h. The reactivity of the dimetalated compounds with monodentate, bidentate, and bis(monodentate) Lewis bases was also studied. The cytotoxic activity of some selected compounds was evaluated against a panel of adenocarcinoma cell lines (colon HCT116 and breast MCF7 and MDA-MB231). Compounds containing the fragment NCH₂CH₂OCH₂CH₂OCH₂CH₂N exhibited a remarkable cytotoxic activity in the three cancer cells assayed, but complexes containing the NCH₂CH₂N fragment showed no activity. It seems that the length and flexibility of the central saturated chain in the imine molecule, as well as its lipophilicity and hydrophilicity, explain the different cytotoxicity of the two series of coordination compounds here reported.