Highly Diastereoselective anti-Dihydroxylation of 3-N,N-Dibenzylaminocyclohex-1-ene N-Oxide

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• 作者：Caroline Aciro ; Stephen G. Davies* ; Wataru Kurosawa ; Paul M. Roberts ; Angela J. Russell ; James E. Thomson
• 刊名：Organic Letters
• 出版年：2009
• 出版时间：March 19, 2009
• 年：2009
• 卷：11
• 期：6
• 页码：1333-1336
• 全文大小：164K
• 年卷期：v.11,no.6(March 19, 2009)
• ISSN：1523-7052

文摘

Oxidation of 3-N,N-dibenzylaminocyclohex-1-ene N-oxide in the presence of Cl₃CCO₂H proceeds with high levels of anti-diastereoselectivity (97% de), with no competing side reactions, allowing access to 1,2-anti-2,3-anti-3-aminocyclohexane-1,2-diol after deprotection.