Microprobe X-ray Absorption Spectroscopic Determination of the Oxidation State of Intracellular Chromium following Exposure of V79 Chinese Hamster Lung Cells to Genotoxic Chromium Complexes
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- 作者：Carolyn T. Dillon ; Peter A. Lay ; Marian Cholewa ; George J. F. Legge ; Antonio M. Bonin ; Terrence J. Collins ; Kimberley L. Kostka ; and Grace Shea-McCarthy
- 刊名：Chemical Research in Toxicology
- 出版年：1997
- 出版时间：May 1997
- 年：1997
- 卷：10
- 期：5
- 页码：533 - 535
- 全文大小：71K
- 年卷期：v.10,no.5(May 1997)
- ISSN：1520-5010
文摘
The oxidation state of intracellular chromium has been determineddirectly in mammalianlung cells exposed to mutagenic and carcinogenic chromium compounds.Microprobe X-rayabsorption spectroscopy (XAS) experiments on single V79 Chinese hamsterlung cells showedthat Cr(VI) and Cr(V) complexes were reduced completely(>90%) to Cr(III) within 4 h ofexposure of the cells. This result provides direct evidence forthe hypothesis that these genotoxicoxidants react rapidly with intracellular reductants.