Alterations in Physical Cross-Linking Modulate Mechanical Properties of Two-Phase Protein Polymer Networks
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- 作者：Xiaoyi Wu ; Rory Sallach ; Carolyn A. Haller ; Jeffrey A. Caves ; Karthik Nagapudi ; Vincent P. Conticello ; Marc E. Levenston ; and Elliot L. Chaikof
- 刊名：Biomacromolecules
- 出版年：2005
- 出版时间：November 2005
- 年：2005
- 卷：6
- 期：6
- 页码：3037 - 3044
- 全文大小：136K
- 年卷期：v.6,no.6(November 2005)
- ISSN：1526-4602
文摘
Physically cross-linked protein-based materials possess a number of advantages over their chemically cross-linked counterparts, including ease of processing and the ability to avoid the addition or removal of chemicalreagents or unreacted intermediates. The investigations reported herein sought to examine the nature ofphysical cross-links within two-phase elastin-mimetic protein triblock copolymer networks through ananalysis of macroscopic viscoelastic properties. Given the capacity of solution processing conditions, includingsolvent type and temperature to modulate the microstructure of two-phase protein polymer networks,viscoelastic properties were examined under conditions in which interphase block mixing had been eitheraccentuated or diminished during network formation. Protein networks exhibited strikingly different propertiesin terms of elastic modulus, hysteresis, residual deformability, and viscosity in response to interdomainmixing. Thus, two-phase protein polymer networks exhibit tunable responses that extend the range ofapplication of these materials to a variety of tissue engineering applications.