Automated Liquid-Liquid Extraction Workstation for Library Synthesis and Its Use in the Parallel and Chromatography-Free Synthesis of 2-Alkyl-3-alkyl-4-(3H)-quinazolinones
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- 作者：Mercedes Carpintero ; Marta Cifuentes ; Rafael Ferritto ; Rubé ; n Haro ; Miguel A. Toledo
- 刊名：Journal of Combinatorial Chemistry
- 出版年：2007
- 出版时间：September 2007
- 年：2007
- 卷：9
- 期：5
- 页码：818 - 822
- 全文大小：229K
- 年卷期：v.9,no.5(September 2007)
- ISSN：1520-4774
文摘
An automated liquid-liquid extraction workstation has been developed. This module processes up to 96samples in an automated and parallel mode avoiding the time-consuming and intensive sample manipulationduring the workup process. To validate the workstation, a highly automated and chromatography-free synthesisof differentially substituted quinazolin-4(3H)-ones with two diversity points has been carried out using isatoicanhydride as starting material.