Automated Liquid-Liquid Extraction Workstation for Library Synthesis and Its Use in the Parallel and Chromatography-Free Synthesis of 2-Alkyl-3-alkyl-4-(3H)-quinazolinones
An automated liquid-liquid extraction workstation has been developed. This module processes up to 96samples in an automated and parallel mode avoiding the time-consuming and intensive sample manipulationduring the workup process. To validate the workstation, a highly automated and chromatography-free synthesisof differentially substituted quinazolin-4(3H)-ones with two diversity points has been carried out using isatoicanhydride as starting material.