Prenylated Benzoylphloroglucinols and Xanthones from the Leaves of Garcinia oblongifolia with Antienteroviral Activity

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• 作者：Hong Zhang ; Ling Tao ; Wen-Wei Fu ; Shuang Liang ; Yi-Fu Yang ; Qing-Hong Yuan ; Da-Jian Yang ; Ai-Ping Lu ; Hong-Xi Xu
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：April 25, 2014
• 年：2014
• 卷：77
• 期：4
• 页码：1037-1046
• 全文大小：410K
• 年卷期：v.77,no.4(April 25, 2014)
• ISSN：1520-6025

文摘

An acetone extract of the leaves of Garcinia oblongifolia showed antiviral activity against enterovirus 71 (EV71) using a cytopathic effect inhibition assay. Bioassay-guided fractionation yielded 12 new prenylated benzoylphloroglucinols, oblongifolins J鈥揢 (1鈥?b>12), and five known compounds. The structures of 1鈥?b>12 were elucidated by spectroscopic analysis including 1D- and 2D-NMR and mass spectrometry methods. The absolute configurations were determined by a combination of a Mosher ester procedure carried out in NMR tubes and ECD calculations. Compared to ribavirin (IC₅₀ 253.1 渭M), compounds 1, 4, and 13 exhibited significant anti-EV71 activity in vitro, with IC₅₀ values of 31.1, 16.1, and 12.2 渭M, respectively. In addition, the selectivity indices of these compounds were 1.5, 2.4, and 3.0 in African green monkey kidney (Vero) cells, respectively.