Expedient Synthesis of C3-Symmetric Hexasubstituted Benzenes via Nicholas Reaction/[2 + 2 + 2] Cycloaddition. New Platforms for Molecular Recognition

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• 作者：Romen Carrillo ; Tomás Martín ; Matías López-Rodríguez ; Fernando Pinacho Crisóstomo
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：January 17, 2014
• 年：2014
• 卷：16
• 期：2
• 页码：552-555
• 全文大小：254K
• ISSN：1523-7052

文摘

An expedient methodology to synthesize macrocyclic compounds in one step based on the Nicholas reaction is disclosed. The key step features two intermolecular reactions followed by an intramolecular reaction from the starting dicobalt hexacarbonyl鈥損ropargylic complex. The macrocycles obtained were modified through [2 + 2 + 2] cycloaddition, generating two new C₃-symmetric hexasubstituted benzene structures suitable for molecular recognition purposes.