Evaluating Indole-Related Derivatives as Precursors in the Directed Biosynthesis of Diazepinomicin Analogues§
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- 作者：Anokha S. Ratnayake ; Jeffrey E. Janso ; Xidong Feng ; Gerhard Schlingmann ; Igor Goljer ; Guy T. Carter
- 刊名：Journal of Natural Products
- 出版年：2009
- 出版时间：March 27, 2009
- 年：2009
- 卷：72
- 期：3
- 页码：496-499
- 全文大小：128K
- 年卷期：v.72,no.3(March 27, 2009)
- ISSN：1520-6025
文摘
The effectiveness of precursor-directed biosynthesis to generate diazepinomicin (1) analogues with varied ring-A substitutents was investigated by feeding commercially available, potential ring-A precursors such as fluorinated tryptophans, halogenated anthranilates, and various substituted indoles into growing actinomycete culture DPJ15 (genus Micromonospora). Two new monofluorinated diazepinomicin analogues (2 and 3) were identified and characterized by spectroscopic methods. Both derivatives showed modest antibacterial activity against the Gram-positive coccus Staphylococcus aureus with MIC values in the range 8−32 μg/mL.