Stereoselective, Ag-Catalyzed Cyclizations To Access Polysubstituted Pyran Ring Systems: Synthesis of C1–C12 Subunit of Madeirolide A

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• 作者：Kazuhiro Watanabe ; Jinming Li ; Nagarathanam Veerasamy ; Ankan Ghosh ; Rich G. Carter
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：April 15, 2016
• 年：2016
• 卷：18
• 期：8
• 页码：1744-1747
• 全文大小：389K
• 年卷期：0
• ISSN：1523-7052

文摘

The exploration into the scope of a silver-catalyzed cyclization (AgCC) of propargyl benzoates for accessing pyran ring systems has been reported. The impact of the degree of substitution, nature of the substitution on the carbon backbone/benzoate moiety, and stereochemistry has been evaluated. The application of this methodology to the synthesis of the C₁–C₁₂ southern fragment of madeirolide A is disclosed.