Quinine and Chloroquine Differentially Perturb Heme Monomer−Dimer Equilibrium

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• 作者：Leah B. Casabianca ; David An ; Jayakumar K. Natarajan ; John N. Alumasa ; Paul D. Roepe ; Christian Wolf ; Angel C. de Dios
• 刊名：Inorganic Chemistry
• 出版年：2008
• 出版时间：July 7, 2008
• 年：2008
• 卷：47
• 期：13
• 页码：6077 - 6081
• 全文大小：319K
• 年卷期：v.47,no.13(July 7, 2008)
• ISSN：1520-510X

文摘

Nuclear magnetic resonance (NMR) measurements of magnetic susceptibility have been utilized to study the equilibrium between two forms (high-spin monomer vs the antiferromagnetically coupled μ-oxo dimer) of ferriprotoporphyrin(IX) as a function of pH. The pH dependence of this equilibrium is significantly altered by the addition of either chloroquine or quinine. Chloroquine promotes the μ-oxo dimer whereas quinine promotes the monomer.