Vitexin Inhibits Inflammatory Pain in Mice by Targeting TRPV1, Oxidative Stress, and Cytokines

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• 作者：Sergio M. Borghi ; Thacyana T. Carvalho ; Larissa Staurengo-Ferrari ; Miriam S. N. Hohmann ; Phileno Pinge-Filho ; Rubia Casagrande ; Waldiceu A. Verri ; Jr.
• 刊名：Journal of Natural Products
• 出版年：2013
• 出版时间：June 28, 2013
• 年：2013
• 卷：76
• 期：6
• 页码：1141-1149
• 全文大小：466K
• 年卷期：v.76,no.6(June 28, 2013)
• ISSN：1520-6025

文摘

The flavonoid vitexin (1) is a flavone C-glycoside (apigenin-8-C-尾-d-glucopyranoside) present in several medicinal and other plants. Plant extracts containing 1 are reported to possess antinociceptive, anti-inflammatory, and antioxidant activities. However, the only evidence that 1 exhibits antinociceptive activity was demonstrated in the acetic acid-induced writhing model. Therefore, the analgesic effects and mechanisms of 1 were evaluated. In the present investigation, intraperitoneal treatment with 1 dose-dependently inhibited acetic acid-induced writhing. Furthermore, treatment with 1 also inhibited pain-like behavior induced by phenyl-p-benzoquinone, complete Freund鈥檚 adjuvant (CFA), capsaicin (an agonist of transient receptor potential vanilloid 1, TRPV1), and both phases of the formalin test. It was also observed that inhibition of carrageenan-, capsaicin-, and chronic CFA-induced mechanical and thermal hyperalgesia occurred. Regarding the antinociceptive mechanisms of 1, it prevented the decrease of reduced glutathione levels, ferric-reducing ability potential, and free-radical scavenger ability, inhibited the production of hyperalgesic cytokines such as TNF-伪, IL-1尾, IL-6, and IL-33, and up-regulated the levels of the anti-hyperalgesic cytokine IL-10. These results demonstrate that 1 exhibits an analgesic effect in a variety of inflammatory pain models by targeting TRPV1 and oxidative stress and by modulating cytokine production.