Collagen Stimulating Effect of Peptide Amphiphile C16鈥揔TTKS on Human Fibroblasts

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• 作者：Roanne R. Jones ; Valeria Castelletto ; Che J. Connon ; Ian W. Hamley
• 刊名：Molecular Pharmaceutics
• 出版年：2013
• 出版时间：March 4, 2013
• 年：2013
• 卷：10
• 期：3
• 页码：1063-1069
• 全文大小：306K
• 年卷期：v.10,no.3(March 4, 2013)
• ISSN：1543-8392

文摘

The collagen production of human dermal and corneal fibroblasts in contact with solutions of the peptide amphiphile (PA) C₁₆鈥揔TTKS is investigated and related to its self-assembly into nanotape structures. This PA is used in antiwrinkle cosmeceutical applications (trade name Matrixyl). We prove that C₁₆鈥揔TTKS stimulates collagen production in a concentration-dependent manner close to the critical aggregation concentration determined from pyrene fluorescence spectroscopy. This suggests that self-assembly and the stimulation of collagen production are inter-related.

Keywords:

peptide amphiphile; Matrixyl; collagen; fibroblasts; skincare