Enantioselective Formal Synthesis of Nectrisine Using a Palladium-Catalyzed Asymmetric Allylic Amination and Cross-Metathesis as Key Steps

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• 作者：Sébastien Soriano ; Mariam Azzouz ; Josep Llaveria ; Patricia Marcé ; M. Isabel Matheu ; Yolanda Díaz ; Sergio Castillón
• 刊名：Journal of Organic Chemistry
• 出版年：2016
• 出版时间：June 17, 2016
• 年：2016
• 卷：81
• 期：12
• 页码：5217-5221
• 全文大小：390K
• 年卷期：0
• ISSN：1520-6904

文摘

A formal enantioselective synthesis of nectrisine, a potent α-glucosidase inhibitor, was carried out starting from butadiene monoepoxide through a synthetic sequence involving enantioselective allylic substitution, cross-metathesis, dihydroxylation, and cyclization.