Charge Transfer through Modified Peptide Nucleic Acids

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• 作者：Emil Wierzbinski ; Arnie de Leon ; Kathryn L. Davis ; Silvia Bezer ; Matth盲us A. Wolak ; Matthew J. Kofke ; Rudy Schlaf ; Catalina Achim ; David H. Waldeck
• 刊名：Langmuir
• 出版年：2012
• 出版时间：January 31, 2012
• 年：2012
• 卷：28
• 期：4
• 页码：1971-1981
• 全文大小：728K
• 年卷期：v.28,no.4(January 31, 2012)
• ISSN：1520-5827

文摘

We studied the charge transfer properties of bipyridine-modified peptide nucleic acid (PNA) in the absence and presence of Zn(II). Characterization of the PNA in solution showed that Zn(II) interacts with the bipyridine ligands, but the stability of the duplexes was not affected significantly by the binding of Zn(II). The charge transfer properties of these molecules were examined by electrochemistry for self-assembled monolayers of ferrocene-terminated PNAs and by conductive probe atomic force microscopy for cysteine-terminated PNAs. Both electrochemical and single molecular studies showed that the bipyridine modification and Zn(II) binding do not affect significantly the charge transfer of the PNA duplexes.