Metachromins U鈥揥: Cytotoxic Merosesquiterpenoids from an Australian Specimen of the Sponge Thorecta reticulata

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• 作者：Simon P. B. Ovenden ; Jonathan L. Nielson ; Catherine H. Liptrot ; Richard H. Willis ; Dianne M. Tapiolas ; Anthony D. Wright ; Cherie A. Motti
• 刊名：Journal of Natural Products
• 出版年：2011
• 出版时间：May 27, 2011
• 年：2011
• 卷：74
• 期：5
• 页码：1335-1338
• 全文大小：692K
• 年卷期：v.74,no.5(May 27, 2011)
• ISSN：1520-6025

文摘

Three new merosesquiterpenoids, metachromins U, V, and W (1鈥?b>3), were isolated from a specimen of the marine sponge Thorecta reticulata collected off Hunter Island, Tasmania, Australia. Structures of the new compounds were elucidated through extensive NMR investigations and comparison with literature values. The cytotoxicities of 1鈥?b>3 were assessed against a panel of human tumor cell lines (SF-268, H460, MCF-7, and HT-29) and a mammalian cell line (CHO-K1). All compounds were found to have 50% growth inhibition activities in the range 2.1鈥?30 渭M, with 2 being the most active (GI₅₀ 2.1鈥?0 渭M).