Efficient Synthesis of (+)-MK7607 and its C-1 Epimer via the Stereoselective Transposition of a Tertiary Allylic Alcohol

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• 作者：Chaemin Lim ; Dong Jae Baek ; Deukjoon Kim ; So Won Youn ; Sanghee Kim
• 刊名：Organic Letters
• 出版年：2009
• 出版时间：June 18, 2009
• 年：2009
• 卷：11
• 期：12
• 页码：2583-2586
• 全文大小：139K
• 年卷期：v.11,no.12(June 18, 2009)
• ISSN：1523-7052

文摘

These studies provide an efficient and stereoselective synthetic route to (+)-MK7607 and its C-1 epimer from a common intermediate in high overall yields. The synthetic methodologies mainly rely on the stereospecific 1,3-allylic transposition of the hindered tertiary alcohol group through a palladium-catalyzed allylic rearrangement as well as a PBr₃-mediated allylic-transposed bromination.