Toxicokinetics, Recovery, and Metabolism of Triclopyr Butotyl (ACTP) Ester in Goats
详细信息 查看全文
- 作者：Tapas K. Sar ; Biplab Bagchi ; Shyamal K. Das ; Tapan K. Mandal ; Animesh K. Chakraborty ; Anjan Bhattacharyya ; and Ashim Choudhury
- 刊名：Journal of Agricultural and Food Chemistry
- 出版年：2002
- 出版时间：July 17, 2002
- 年：2002
- 卷：50
- 期：15
- 页码：4202 - 4209
- 全文大小：109K
- 年卷期：v.50,no.15(July 17, 2002)
- ISSN：1520-5118
文摘
Toxicokinetic behavior, recovery, and metabolism studies of ACTP ester and its effect on cytochromeP450 content of liver microsomal pellet were carried out in black Bengal goat after a single intravenousadministration of 11.88 mg kg-1 and consecutive oral administration of 79.22 mg kg-1 for 7 days.ACTP ester achieved a maximum blood concentration of 42.64 ± 4.26 
g mL-1 at 0.08 h afterintravenous administration followed by a sharp decline until 0.5 h, and the minimum blood concentrationwas recorded at 36 h (1.93 ± 0.14 g mL-1) postdosing. The kinetic behavior of ACTP ester followeda "two-compartment open model". Comparatively shorter 
(0.81 ± 0.02 h-1) and greater t1/2() (0.86± 0.03 h) indicated a slower rate of distribution of ACTP ester in goat. The t1/2(
) (14.83 ± 1.49 h)and Vd(area) (0.91 ± 0.19 L kg-1) suggested a longer elimination phase with general distribution in allcompartments of the body. The higher T/B and K12/K21 values associated with a lower fc valuesuggested longer persistence in the tissue compartment at higher concentration. The higher ClRcompared to ClH indicated the major amount was eliminated by the kidney. Maximum concentrationof ACTP ester including its metabolites, triclopyr acid and trichloropyridinol, was excreted throughurine at 48 h. The recovery of ACTP ester including metabolites after repeated nontoxic oral doseadministration was 70.09%, of which recovery from feces was 4.45%, suggesting the major portionof administered ACTP ester was absorbed through the gastrointestinal tract of the goat. All of thetissues contained ACTP ester and its metabolites. ACTP ester did not alter the cytochrome P450content of the liver tissue following repeated nontoxic oral dose administration for 7 days.Keywords: Toxicokinetics; recovery; ACTP ester; metabolites; cytochrome P450; goat
g mL-1 at 0.08 h afterintravenous administration followed by a sharp decline until 0.5 h, and the minimum blood concentrationwas recorded at 36 h (1.93 ± 0.14 g mL-1) postdosing. The kinetic behavior of ACTP ester followeda "two-compartment open model". Comparatively shorter (0.81 ± 0.02 h-1) and greater t1/2() (0.86± 0.03 h) indicated a slower rate of distribution of ACTP ester in goat. The t1/2() (14.83 ± 1.49 h)and Vd(area) (0.91 ± 0.19 L kg-1) suggested a longer elimination phase with general distribution in allcompartments of the body. The higher T/B and K12/K21 values associated with a lower fc valuesuggested longer persistence in the tissue compartment at higher concentration. The higher ClRcompared to ClH indicated the major amount was eliminated by the kidney. Maximum concentrationof ACTP ester including its metabolites, triclopyr acid and trichloropyridinol, was excreted throughurine at 48 h. The recovery of ACTP ester including metabolites after repeated nontoxic oral doseadministration was 70.09%, of which recovery from feces was 4.45%, suggesting the major portionof administered ACTP ester was absorbed through the gastrointestinal tract of the goat. All of thetissues contained ACTP ester and its metabolites. ACTP ester did not alter the cytochrome P450content of the liver tissue following repeated nontoxic oral dose administration for 7 days.Keywords: Toxicokinetics; recovery; ACTP ester; metabolites; cytochrome P450; goat