A Novel Anabolic Agent: A Simvastatin Analogue without HMG-CoA Reductase Inhibitory Activity
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- 作者：Kuang-Chan Hsieh ; Chai-Lin Kao ; Chien-Wei Feng ; Zhi-Hong Wen ; Hsin-Fang Chang ; Shu-Chun Chuang ; Gwo-Jaw Wang ; Mei-Ling Ho ; Shou-Mei Wu ; Je-Ken Chang ; Hui-Ting Chen
- 刊名：Organic Letters
- 出版年：2014
- 出版时间：September 5, 2014
- 年：2014
- 卷：16
- 期：17
- 页码：4376-4379
- 全文大小：313K
- ISSN：1523-7052
文摘
For the first time, structural information regarding the role of simvastatin in bone anabolism is described, and a bone-specific statin is introduced. Polyaspartate-conjugated simvastatin was synthesized by solid-phase synthesis with the assistance of microwave irradiation. It displays significant bone targeting and bone formation with less toxicity than simvastatin.