Stereospecific Preparations of P-Stereogenic Phosphonothioates and Phosphonoselenoates
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- 作者：Wei-Min Wang ; Li-Juan Liu ; Lan Yao ; Fan-Jie Meng ; Yong-Ming Sun ; Chang-Qiu Zhao ; Qing Xu ; Li-Biao Han
- 刊名：Journal of Organic Chemistry
- 出版年：2016
- 出版时间：August 5, 2016
- 年：2016
- 卷：81
- 期：15
- 页码：6843-6847
- 全文大小：270K
- 年卷期：0
- ISSN：1520-6904
文摘
P-Stereogenic phosphonothioates and phosphonoselenoates were readily prepared utilizing RP-menthyl phenylphosphite 1 by two methods. The first method used elemental sulfur or selenium to react with 1, followed by alkylation of the intermediates with alkyl halides. The second used 1 to react with disulfide or diselenide. Both methods stereospecifically produced the title compounds in nearly quantitative yields under mild conditions. Stereospecific chalcogenation of the phosphoryl was proposed as the key step in these reactions.