Carboxylate Directed Cross-Coupling Reactions in the Synthesis of Trisubstituted Benzoic Acids
详细信息 查看全文
- 作者：Ioannis N. Houpis ; Changkang Huang ; Ulrike Nettekoven ; Jason G. Chen ; Renmao Liu ; Martine Canters
- 刊名：Organic Letters
- 出版年：2008
- 出版时间：December 18, 2008
- 年：2008
- 卷：10
- 期：24
- 页码：5601-5604
- 全文大小：134K
- 年卷期：v.10,no.24(December 18, 2008)
- ISSN：1523-7052
文摘
The carboxylate anion has been used as a directing group to effect selective ortho-substituted derivatives 3 (>99:1 selectivity 50−80% yield). The solvent, base, and equivalents of base are the determining factors for the success of this reaction. The directing effect can be reversed by the appropriate use of phosphine ligands to prepare the para-substituted 4 selectively (ca. 12:1 selectivity).