Substituent-Controlled Chemoselective Cleavage of C═C or Csp2–C(CO) Bond in α,β-Unsaturated Carbonyl Compounds with H-Phosphonates Leading to β-Ketophosphonates

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• 作者：Yao Zhou ; Changqing Rao ; Shaoyu Mai ; Qiuling Song
• 刊名：Journal of Organic Chemistry
• 出版年：2016
• 出版时间：March 4, 2016
• 年：2016
• 卷：81
• 期：5
• 页码：2027-2034
• 全文大小：543K
• ISSN：1520-6904

文摘

An unprecedented substituent-controlled chemoselective cleavage of C═C double bond or C(sp²)–C(CO) bond along with aerobic phosphorylation of α,β-unsaturated carbonyl compounds with H-phosphonates through a radical process has been disclosed. The current strategy provides an access to β-ketophosphonates under mild conditions with a wide substrate scope.