Synthesis of Biaryl Tertiary Amines through Pd/Norbornene Joint Catalysis in a Remote C鈥揌 Amination/Suzuki Coupling Reaction
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- 作者：Changqing Ye ; Hui Zhu ; Zhiyuan Chen
- 刊名：Journal of Organic Chemistry
- 出版年：2014
- 出版时间：September 19, 2014
- 年：2014
- 卷：79
- 期：18
- 页码：8900-8905
- 全文大小：418K
- ISSN：1520-6904
文摘
Here, we report on an efficient palladium/norbornene-catalyzed domino reaction of aryl halide, O-acyl hydroxylamine (R1R2N-OBz), and aromatic pinacol boronate (R-Bpin), selectively affording a series of biaryl tertiary amines in good to high yields with excellent functional group tolerance. This catalytic reaction provides a new opportunity for the convergent synthesis of biaryl amines from easily accessible starting materials.