Domino N鈭扝/C鈭扝 Bond Activation: Copper-Catalyzed Synthesis of Nitrogen-Bridgehead Heterocycles Using Azoles and 1,4-Dihalo-1,3-dienes

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• 作者：Qian Liao ; Liyun Zhang ; Shutao Li ; Chanjuan Xi
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：January 21, 2011
• 年：2011
• 卷：13
• 期：2
• 页码：228-231
• 全文大小：197K
• 年卷期：v.13,no.2(January 21, 2011)
• ISSN：1523-7052

文摘

Copper-catalyzed tandem coupling of 1,4-dihalo-1,3-dienes with azoles via an N鈭扝 bond and its adjacent C鈭扝 bond activation has been described. The reaction exhibits good regioselectivity when unsymmetrical 1,4-dihalo-1,3-diene is employed. This method provided a novel route to the synthesis of nitrogen-bridgehead azolopyridine derivatives.