Enantiomer Separations in Capillary Electrophoresis in the Case of Equal Binding Constants of the Enantiomers with a Chiral Selector: Commentary on the Feasibility of the Concept

详细信息    查看全文

• 作者：Bezhan Chankvetadze ; Wolfgang Lindner ; and Gerhard K. E. Scriba
• 刊名：Analytical Chemistry
• 出版年：2004
• 出版时间：July 15, 2004
• 年：2004
• 卷：76
• 期：14
• 页码：4256 - 4260
• 全文大小：63K
• 年卷期：v.76,no.14(July 15, 2004)
• ISSN：1520-6882

文摘

It is generally acknowledged that enantiomer separationsin capillary electrophoresis are based on differences inthe affinities of the analyte enantiomers toward the chiralselector expressed as equilibrium constants of the resulting temporary diastereomeric associates. However, as canbe derived from theoretical considerations, a separationof enantiomers by CE is in principle also possible solelybased on differences in the mobilities of the temporarydiastereomeric complexes per se, when equal bindingconstants between analyte enantiomers and the chiralselector are assumed and observed.