Astemizole Derivatives as Fluorescent Probes for hERG Potassium Channel Imaging

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• 作者：Beilei Wang ; Zhenzhen Liu ; Zhao Ma ; Minyong Li ; Lupei Du
• 刊名：ACS Medicinal Chemistry Letters
• 出版年：2016
• 出版时间：March 10, 2016
• 年：2016
• 卷：7
• 期：3
• 页码：245-249
• 全文大小：321K
• ISSN：1948-5875

文摘

The detection and imaging of hERG potassium channels in living cells can provide useful information for hERG-correlation studies. Herein, three small-molecule fluorescent probes, based on the potent hERG channel inhibitor astemizole, for the imaging of hERG channels in hERG-transfected HEK293 cells (hERG-HEK293) and human colorectal cancer cells (HT-29), are described. These probes are expected to be applied in the physiological and pathological studies of hERG channels.