Asperterrestide A, a Cytotoxic Cyclic Tetrapeptide from the Marine-Derived Fungus Aspergillus terreus SCSGAF0162

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• 作者：Fei He ; Jie Bao ; Xiao-Yong Zhang ; Zheng-Chao Tu ; Yi-Ming Shi ; Shu-Hua Qi
• 刊名：Journal of Natural Products
• 出版年：2013
• 出版时间：June 28, 2013
• 年：2013
• 卷：76
• 期：6
• 页码：1182-1186
• 全文大小：237K
• 年卷期：v.76,no.6(June 28, 2013)
• ISSN：1520-6025

文摘

A new cytotoxic and antiviral cyclic tetrapeptide, asperterrestide A (1), a new alkaloid, terremide C (2), and a new aromatic butenolide, aspernolide E (3), together with 10 known compounds were isolated from the fermentation broth of the marine-derived fungus Aspergillus terreus SCSGAF0162. Their structures were elucidated by spectroscopic analysis, and the absolute configuration of 1 was determined by the Mosher ester technique and analysis of the acid hydrolysates using a chiral-phase HPLC column. Compound 1 contains a rare 3-OH-N-CH₃-Phe residue and showed cytotoxicity against U937 and MOLT4 human carcinoma cell lines and inhibitory effects on influenza virus strains H1N1 and H3N2.