Anti-HIV-1 Protease Activity of Lanostane Triterpenes from the Vietnamese Mushroom Ganoderma colossum

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• 作者：Riham Salah El Dine ; Ali M. El Halawany ; Chao-Mei Ma ; Masao Hattori
• 刊名：Journal of Natural Products
• 出版年：2008
• 出版时间：June 2008
• 年：2008
• 卷：71
• 期：6
• 页码：1022 - 1026
• 全文大小：103K
• 年卷期：v.71,no.6(June 2008)
• ISSN：1520-6025

文摘

Four new lanostane triterpenes, colossolactone V (1), colossolactone VI (2), colossolactone VII (3), and colossolactone VIII (4), were isolated from the fruiting bodies of the Vietnamese mushroom Ganoderma colossum, together with the known compound colossolactone E (5). The structures of 1−4 were assigned on the basis of spectroscopic evidence, and their absolute configurations were determined by CD spectroscopy and the Mosher ester method. Compounds 1−5, as well as two previously isolated compounds [schisanlactone A (6) and colossolactone G (7)] from the same mushroom, were evaluated for inhibition of HIV-1 protease, with IC₅₀ values for the most potent compounds ranging from 5 to 13 µg/mL.