Synthesis of the Epoxyquinol Dimer RKB-3564 D: Utilization of an Alkoxysilanol To Promote [4 + 4] Dimerization

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• 作者：Chaomin Li and John A. Porco ; Jr.
• 刊名：Journal of the American Chemical Society
• 出版年：2004
• 出版时间：February 11, 2004
• 年：2004
• 卷：126
• 期：5
• 页码：1310 - 1311
• 全文大小：77K
• 年卷期：v.126,no.5(February 11, 2004)
• ISSN：1520-5126

文摘

The synthesis of the epoxyquinol dimer RKB-3564 D (3) is reported, employing an alkoxysilanol protecting group to redirect the inherently favored [4 + 2] dimerization of 2H-pyran monomers to a [4 + 4] manifold. Preliminary mechanistic studies indicate that the [4 + 4] dimerization may occur through a stepwise, ionic process.